Lars J. Grimm

This study estimates tumor mitotic ages in neuroblastoma patients to show aggressive tumors start growing after infancy, making them undetectable by infant screening.

This paper estimates the age of breast cancers using an epigenetic clock based on methylation data, finding that younger tumors are more aggressive while older tumors show higher immune infiltration.

This study reconstructs DCIS growth dynamics using somatic mutation topography, revealing a multiclonal, branching morphogenesis-like pattern consistent with a new Comet model of tumorigenesis.