Shannon T. Holloway

This study estimates tumor mitotic ages in neuroblastoma patients to show aggressive tumors start growing after infancy, making them undetectable by infant screening.

The paper introduces a Hi-C informed kernel association test to integrate 3D genome structure into variant-set association analysis for WGS data, showing improved detection of rare-variant sets.

This paper estimates the age of breast cancers using an epigenetic clock based on methylation data, finding that younger tumors are more aggressive while older tumors show higher immune infiltration.

This paper introduces a new framework for CNV association analysis in whole genome sequencing data, identifying additional CNVs linked to Alzheimer's Disease.

This study reconstructs DCIS growth dynamics using somatic mutation topography, revealing a multiclonal, branching morphogenesis-like pattern consistent with a new Comet model of tumorigenesis.