Author

Iago De Castro Silva

University of MiamiORCID 0000-0002-3898-6173Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Haleh AmirianiD· 2 shared Jashodeep DattaiD· 2 shared Nagaraj S. NagathihalliiD· 2 shared Nipun B. MerchantiD· 2 shared Siddharth MehraiD· 2 shared Anna BianchiiD· 1 shared Anna Bianchi· 1 shared Austin R. DoschiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Haleh AmirianORCID

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2 papers

Recent·Most cited

Cancer BiologyCancer Immunology ImmunotherapyPeer-reviewedJun 23, 2025

Cell-specific nanoengineering strategy disrupts tolerogenic signaling from myeloid-derived suppressor cells to invigorate antitumor immunity in pancreatic cancer

Nilesh Deshpande, Anna Bianchi, Haleh Amirian…·Jashodeep Datta

The paper develops CXCR2-homing nanoparticles to specifically target PMN-MDSCs in PDAC, reducing arginase activity and enhancing T-cell activity without causing neutropenia.

10 citations

mouseexperimental assay

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Cancer BiologyCellular and Molecular Gastroenterology and HepatologyPeer-reviewedJan 1, 2025

CREB drives acinar cells to ductal reprogramming and promotes pancreatic cancer progression in preclinical models of alcoholic pancreatitis

Supriya Srinivasan, Siddharth Mehra, Sudhakar Jinka…·Nagaraj S. Nagathihalli

This study shows CREB promotes acinar-to-ductal reprogramming and pancreatic cancer progression in alcoholic pancreatitis models by enhancing fibrosis and tumor growth.

9 citations

mousebulk RNA-seq

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