Michelle Dawn Garrett

This study identifies reduced 4E-BP1 activity and increased cap-dependent protein synthesis as mechanisms of acquired resistance to the AKT inhibitor capivasertib in ovarian cancer.

This study identifies molecular pathways of madecassic acid's anti-liver cancer activity using chemical proteomics and RNAseq, showing its interactions with proteins related to metabolism and nucleic acid processing.

This study characterizes phenotypic plasticity in EGFR inhibitor-resistant NSCLC cell lines, showing diverse resistance mechanisms and metabolic adaptations across sublines.

This study identifies drug-resistant sublines of TNBC cell lines and finds that resistance mechanisms are unique and unpredictable, suggesting new potential drug targets.

This study synthesizes and tests six silybin derivatives, finding one shows 12-fold stronger cytotoxicity against liver cancer cells than silybin itself.

The paper develops sequence-defined oligophosphoesters to inhibit the KRAS G12D/RAF1 interaction, achieving low IC50 values and selectivity for the mutant form.