Aifu Lin

The paper presents 320 nearly-complete East Asian genome assemblies, revealing new genetic diversity and structural variations not present in existing global pangenomes.

This study identifies C9orf50 as a spliceosome regulator that, when targeted, converts immunologically cold tumors to hot ones by enhancing immunogenicity and T cell recruitment.

This study identifies a zebrafish model of IBD by knocking out Ctla-4, showing similar intestinal inflammation and immune dysregulation to mammalian IBD.

This study uses single-cell RNA sequencing to show zebrafish kidney cells can generate both blood cells and adaptive antiviral immunity, acting as a dual-functional organ.