Cancer BiologybioRxivPreprint
Somatic mutation of Afadin leads to anchorage independent survival and metastatic growth of breast cancer through alpha E-catenin dependent destabilization of the adherens junction
Max A. K. Rätze, Lotte N.F.L. Enserink, Noboru Ishiyama…·Patrick W.B. Derksen
This study identifies a somatic Afadin mutation that destabilizes adherens junctions and promotes metastatic growth in breast cancer by disrupting E-catenin binding.