Cancer BiologyGenome biologyPeer-reviewed
Enhancer plasticity in endometrial tumorigenesis demarcates non-coding somatic mutations and 3D-genome alterations boosting the oncogenic driver ESR1
Sebastian Gregoricchio, Aleksandar Kojic, Marlous Hoogstraat…·Wilbert T. Zwart
The paper identifies enhancer plasticity and 3D-genome alterations in endometrial cancer that boost ESR1 expression through non-coding mutations and risk variants.