Jonathan U. Peled

The paper links sugar-rich foods to microbiome disruption during antibiotic treatment in patients and mice.

This study shows that higher dietary fiber intake improves survival and reduces GVHD in hematopoietic cell transplant patients, with microbiome-mediated effects.

This study uses spatial transcriptomics and single-cell analysis to reveal how MDS bone marrow microenvironments are altered, showing TGFβ dysregulation in malignant cells and immune escape mechanisms.

The paper identifies metabiosis, an ecological dependency where Bacteroides supports Pseudomonadota growth, increasing gut-borne bloodstream infection risk in allo-HCT patients.

This study compares the effects of two GVHD prophylaxis regimens on the gut microbiome in allo-HCT recipients and finds that while PTCy reduces microbiome diversity and bile acid metabolism, it is linked to better clinical outcomes.

The paper introduces FLORAL, a method for analyzing longitudinal microbiome data to identify biomarkers associated with time-varying outcomes, showing improved sensitivity and FDR control in simulations and real-world applications.

FLORAL improves microbial feature selection for microbiome data by addressing survival endpoints, longitudinal samples, and sequencing biases, showing better false-positive control and sensitivity in simulations and real data.

This paper introduces a leucine zipper-based sorting system to generate T cells with multiple CARs and switch receptors, enhancing their ability to target heterogeneous tumors.

The paper compiles shotgun metagenomic data from stool samples of hospitalized hematopoietic cell transplant patients to enhance microbiome analysis beyond taxonomic composition.