Author

Xiaoke Xu

Broad InstituteORCID 0000-0002-4033-1774Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Organism:human· 1

Frequent Co-Authors

Howard S. FoxiD· 2 shared Katy M. EmanueliD· 2 shared Meng NiuiD· 2 shared Amy Grayson· 1 shared Andrew J. TreaseiD· 1 shared Benjamin G. Lamberty· 1 shared Bingqiu XiuiD· 1 shared Chuqian LiangiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

Howard S. FoxORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMay 29, 2026

Circadian misalignment underlies immune escape in breast cancer

Chuqian Liang, Zunpeng Liu, Xiaoke Xu…·Myles Brown

The paper identifies circadian misalignment between cancer and immune cells in breast tumors as a mechanism of immune evasion and therapeutic resistance.

DOI 10.64898/2026.05.26.726543

mousescRNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintAug 6, 2025

Cocaine Acts Through Sigma-1 to Enhance HIV Infection of Microglia

Oluwatofunmi Oteju, Xiaoke Xu, Taylor Kist…·Peter J. Gaskill

This study shows cocaine enhances HIV infection of microglia via sigma-1 activation, which modulates the UPR to boost viral replication and immune evasion.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky

MicrobiologyPLoS PathogensPeer-reviewedSep 16, 2024

Microglia and macrophages alterations in the CNS during acute SIV infection: a single-cell analysis in rhesus macaques

Xiaoke Xu, Meng Niu, Benjamin G. Lamberty…·Howard S. Fox

This study uses single-cell RNA sequencing to analyze microglia and macrophages in rhesus macaques during acute SIV infection, revealing changes in cell clusters and gene expression linked to inflammation and neurodegeneration.

15 citations

ratscRNA-seq

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