Katrin Karbstein

The paper shows that the ubiquitin-proteasome system degrades Rps26 during high salt stress in yeast, enabling the formation of Rps26-deficient ribosomes and stress resistance.

The paper investigates how Rio1 monitors 18S rRNA cleavage quality and prevents miscleaved rRNA from causing translation defects through ribosome collisions.

The paper investigates how the non-globular structure of the assembly factor Ltv1 uses structural plasticity to coordinate 40S ribosome subunit maturation and reveals its role in quality control and human disease.

The paper investigates how the Ltv1 mutation affects ribosome assembly and rRNA folding in the small ribosomal subunit head.

The paper shows that chaperones repair oxidized ribosomes by releasing damaged ribosomal proteins and incorporating newly synthesized ones, revealing a novel mechanism for ribosome repair under oxidative stress.

The paper shows how the chaperone Tsr2 releases and recycles Rps26 from ribosomes during stress, enabling a reversible ribosome response without bypassing quality control.

The paper identifies a kinase-dependent checkpoint involving Rio1, Nob1, and Pno1 that prevents immature ribosomes from entering the translating pool, ensuring proper maturation and preventing fidelity defects.