Marcus Alexander Mall

This study uses single-cell transcriptomics to show that SARS-CoV-2 variants reshape pediatric upper-airway immunity differently from adults.

This paper develops a cell-permeable nanobody to restore function of the misfolded F508del-CFTR protein in CF bronchial epithelial cells.

This paper introduces confocal reflection microscopy as a method to measure airway surface liquid height in cystic fibrosis models without perturbing the ASL, showing it is sensitive to detect ASL changes and therapeutic responses.

This study uses a nanobody to stabilize mutant CFTR, revealing a novel active conformation and improving its function in cystic fibrosis.

This study identifies age-related rewiring of type I IFN signaling in immune cells linked to increased inflammation and altered antibody responses in COVID-19.

This study uses X-ray Velocimetry to identify peripheral ventilation changes in a mouse model of muco-obstructive lung disease.

This study uses proteomics to compare the systemic effects of two CFTR modulator therapies in CF patients, finding that ELX/TEZ/IVA leads to proteome changes closer to healthy profiles.

This study characterizes the viscoelastic properties of Bovine Submaxillary Mucin (BSM) hydrogels and examines the effects of additives on their rheological behavior.

This study examines ileal mucus viscoelastic properties in Crohn's disease patients and controls, finding significant differences in viscoelasticity and mesh size.

This study identifies ELF5 as a risk gene for severe COVID-19 using genetic and single-cell expression data, showing its specific expression in respiratory epithelial cells.