Philipp Mertins

This study investigates cardiac myofibril remodeling in Burmese pythons during digestion using multi-omics approaches, revealing post-translational modifications as key to increased contractility.

This study shows that neuroblastoma-derived sEVs retain genomic subgroup and lineage state signatures from their parental cells.

This paper identifies prognostic biomarkers for multiple myeloma by integrating multi-omics data and shows that proteomic features outperform genomic or transcriptomic data in classification.

This paper shows that myeloid cell recruitment drives right ventricular dysfunction in HFpEF through sterile inflammation in both mice and humans.

This study quantitatively profiles JMJD6-catalyzed lysine hydroxylation, revealing a graded, residue-dependent response to oxygen availability in lysine-rich regions.

This study identifies SVIL haploinsufficiency as a cause of hypertrophic cardiomyopathy by impairing mechanotransduction and cellular energetics, with potential therapeutic implications for mitochondrial-targeted treatments.

This study investigates how TMPRSS2 affects ACE2 trafficking and shedding, showing that TMPRSS2 interaction alters ACE2 processing and glycosylation impacts these effects in vivo.

This study identifies endothelial YAP/TAZ signaling as a driver of sex-divergent vascular remodeling in HFpEF, linking cardiometabolic stress to microvascular changes through YAP1 and ESM1.

This study reveals that autophagy selectively clears the endoplasmic reticulum during inflammation-induced muscle atrophy, challenging the classical view of atrophy as a uniform degradation process.

This study identifies HAP40 as a proteostasis regulator that controls HTT interactions and mHTT secretion, impacting cellular homeostasis and pathobiology.

This study shows that MNK1 and MNK2 have distinct roles in social and cognitive behaviors by regulating different aspects of the synaptic proteome and phosphoproteome in knockout mice.

This study identifies molecular differences in hazelnut allergy using multi-omics analysis, finding IL-5 as a key biomarker and linking the condition to vitamin D metabolism, hyper-IgE genes, and epithelial barrier dysfunction.

This study shows that butyrate improves diastolic function and reduces fibrosis in hypertensive HFpEF rats by serving as an alternative energy source.

This study shows that autophagy in adipocytes limits obesity-related fibrosis by controlling purine nucleoside metabolism and macrophage polarization.

This study rapidly depletes UPF1 in human cells to investigate NMD-regulated transcriptome dynamics, identifying core transcripts and biological processes affected.

The paper uses multi-omic profiling to study early regulatory changes in dexamethasone-induced muscle atrophy in C2C12 cells, identifying mitochondrial gene expression and alternative splicing alterations.

The paper introduces SPIED-DIA, a phosphoproteomics method, to identify synergistic signaling responses in colon cancer cells to MEK inhibition and growth factor stimulation.

This study identifies BIRC5 as a targetable vulnerability in TP53 mutant AML, showing that survivin/IAP inhibitors can overcome therapy resistance.

The paper shows UBE3C regulates cortical neurogenesis and glial fate through m6A methylation, with mutations disrupting this process and offering therapeutic targets.

This study examines how sialylated glycans and molecular size of bovine submaxillary mucins affect influenza virus inhibition.

This study identifies LINC01503-MP, a mitochondrial microprotein derived from an lncRNA, which promotes cell proliferation and oxidative metabolism in colorectal cancer cells.

This study links mHTTex1 aggregation in neurons to synaptic dysfunction and early mortality in HD flies through machine learning analysis and RNAi knockdown experiments.

The paper develops methods to collect intestinal interstitial fluid from different segments and shows segment-specific differences in microbiota-derived metabolites, cytokines, and proteins compared to plasma and serum.

This study uses proteomics to compare the systemic effects of two CFTR modulator therapies in CF patients, finding that ELX/TEZ/IVA leads to proteome changes closer to healthy profiles.

This study identifies TENM4 as an essential extracellular linker protein for mechanotransduction in mechanoreceptors, showing its role in touch sensitivity.

This paper introduces DIA-SiS, a method combining DIA with spike-in SILAC to improve proteome coverage and quantification, showing better performance than label-free approaches.

This study identifies Vangl1 as a key mediator of flow-dependent cell dynamics in vascular remodeling through planar cell polarity signaling.

This study characterizes the viscoelastic properties of Bovine Submaxillary Mucin (BSM) hydrogels and examines the effects of additives on their rheological behavior.

The paper identifies branch- and length-specific ubiquitin chain interactors in humans and yeast, revealing how different Ub architectures are decoded by proteins.

The paper identifies novel E-box interactors using proximity labeling proteomics in mouse fibroblasts, revealing proteins involved in circadian transcription regulation.