Wenhao Tang

The paper develops a method to model capture efficiency in scRNA-seq data to improve inference of transcriptome-wide burst kinetics.

The paper investigates how RNA Polymerase II initiation rates scale with cell size in fission yeast, showing that RNAPII is a limiting factor for transcriptional scaling.

bayNorm provides a Bayesian method for normalizing, imputing, and recovering gene expression in scRNA-seq data, improving accuracy and reducing batch effects.

The paper uses scRNA-seq and imaging to study gene expression heterogeneity in fission yeast under different environmental conditions, revealing how gene expression varies during growth and stress responses.