Denis Yudin

This study investigates the DNA targeting mechanisms of five bacterial Argonaute proteins in vitro and in vivo, revealing their ability to cleave DNA and defend against bacteriophages.

The paper shows that bacterial Argonaute proteins assist in cell division in E. coli under topoisomerase inhibitor stress by processing DNA replication termination sites.

This study shows that the bacterial Argonaute nuclease CbAgo uses DNA interference to cleave multicopy genetic elements like plasmids and transposons by generating small DNA guides through cooperation with repair machinery.

This study identifies two mesophilic prokaryotic Argonautes that function as DNA-guided DNA nucleases at physiological temperatures, expanding their potential for genomic applications.