Cihan Taştan

This study uses CRISPR/Cas12a to target and cleave Wheat Dwarf Virus genomes without genetic modification, showing effective antiviral activity in vitro.

This paper presents an AI-guided framework for designing CAR-T cells for solid tumors by integrating antigen prioritization, safety-by-design architectures, and LLM-assisted reasoning.

The paper analyzes PBMCs from astronauts before and during spaceflight to show microgravity induces telomere elongation, DNA repair activation, and miRNA suppression, suggesting a molecular longevity program in immune cells.

This study identifies LOC genes with significant expression changes in astronauts during spaceflight, suggesting they may serve as biomarkers for microgravity adaptation.

This study examines haematological and T cell changes in astronauts during short-term spaceflight, finding stable parameters but suggesting further research is needed for long-term immune adaptations.

This study uses CRISPR/Cas9 to target and reduce antibiotic resistance genes in MRSA, significantly decreasing resistance to multiple antibiotics.

This study creates an in vitro model of Wu Syndrome using genetic modification in neural cell lines to characterize new GRIA3 variants and their functional effects.

This paper develops and tests two CD19-specific CAR-T cell designs, showing that PHA-activated CAR19BB-T cells provide prolonged persistence and enhanced anti-tumor effects in preclinical models of ALL.

This study evaluates XNA-DNA-ASO sequences for enhancing SMN protein expression and cell viability in SMA fibroblasts, showing improved stability and reduced toxicity compared to conventional ASOs.

This paper introduces CRISPR.BOT, a robotic system for automated genetic engineering tasks, achieving high-purity single-cell subcloning and reducing labor and costs in biosafety level 3 experiments.

This study uses CRISPR-Prime Editing to correct two point mutations in the SMN2 gene, increasing SMN expression in SMA-related cells.