Arik Horne

This paper integrates transcriptome and chromatin state data to develop a scalable pipeline for drug discovery, predicting cancer cell line sensitivity and guiding compound development.

The paper generates synthetic embryo-like structures from ESCs through transcription factor-mediated reprogramming, showing implantation and decidual tissue formation.

This study uses single-cell RNA-seq and computational methods to analyze macrophage states in COPD patients, revealing transcriptional changes and metabolic shifts associated with the disease.