Jun Ding

CpGPT is a foundation model for DNA methylation analysis that outperforms specialized models in aging-related tasks and can impute methylation profiles across diverse conditions.

This study finds that blood mitochondrial DNA copy number is consistently associated with personality traits and mediates the link between personality and mortality in two genetic cohorts.

The paper examines the concordance and characteristics of mitochondrial heteroplasmic mutations in maternal pairs of European and African ancestry, finding higher concordance in close relatives and associations with age and nuclear genome regions.