Dongxue Wang

The paper introduces an automated system for high-throughput proteomic data generation, demonstrating its robustness and application in spatial proteomics and plasma/cell line profiling.

This paper develops a time-resolved fluorescence resonance energy transfer (TR-FRET) assay for screening small molecule inhibitors targeting the SYK and FCER1G interaction, identifying hematoxylin as a hit.

The paper identifies two covalent inhibitors that disrupt the interaction between SYK's tandem SH2 domains and FCER1G phospho-ITAM, potentially beneficial for Alzheimer's disease therapy.

The paper compares transcription initiation directionality in plants and animals, finding unidirectional initiation in plants and bidirectional in animals, with distinct chromatin modification patterns.

The paper quantifies protein-to-mRNA (PTR) ratios across 29 human tissues and identifies sequence determinants influencing these ratios, finding many new post-transcriptional regulatory elements.

The paper creates a proteome and transcriptome atlas of 29 human tissues, revealing differences in mRNA-protein abundance and challenges in proteogenomics.