Author

Sébastien C. Ortiz

Manchester Academic Health Science CentreORCID 0000-0002-4403-9519Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:drug response / drug discovery· 1 Organism:fungi (other)· 1 Organism:human· 1

Frequent Co-Authors

Aaron A. HoskinsiD· 1 shared Andrew ThomiD· 1 shared Christina M. HulliD· 1 shared Henrik Vollmer· 1 shared Joshua C. Paulson· 1 shared Joshua Davies· 1 shared Margherita BertuzziiD· 1 shared Megan C. McKeoniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMicrobiology

Aaron A. HoskinsORCID

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2 papers

Recent·Most cited

MicrobiologymBioPeer-reviewedOct 22, 2025

Cryptococcus displays spore-specific invasion of alveolar epithelial cells

Sébastien C. Ortiz, Rachael Fortune‐Grant, Andrew Thom…·Margherita Bertuzzi

This study shows Cryptococcus spores invade alveolar epithelial cells in vitro and in vivo, suggesting these cells may serve as an intracellular niche for dissemination and latency.

2 citations

humanexperimental assay

𝕏 PostBluesky

MicrobiologymSpherePeer-reviewedJun 23, 2025

The pre-mRNA Splicing Modulator Pladienolide B Inhibits Cryptococcus neoformans Germination and Growth

Sierra L. Love, Megan C. McKeon, Henrik Vollmer…·Aaron A. Hoskins

This study shows that pladienolide B inhibits Cryptococcus neoformans growth and spore germination, with enhanced efficacy when combined with FK506 or clorgyline.

1 citation

fungi (other)experimental assay

𝕏 PostBluesky