Cancer BiologybioRxivPreprint
VHL loss enables immune checkpoint blockade therapy by boosting type I interferon response.
Meng Jiao, Xuhui Bao, Mengjie Hu…·Chuan‐Yuan Li
This study shows that VHL loss in ccRCC enhances anti-PD-1 therapy efficacy by increasing type I interferon response through HIF1/HIF2-mediated mtDNA leakage.
2 citations