Author

Yanfeng Xing

University of ChicagoORCID 0000-0002-4549-8370Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Assay:proteomics· 1 Approach:statistical model· 1

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Jack W. SzostakiD· 1 shared Xiwen JiaiD· 1 shared Ziyuan FangiD· 1 shared

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2025-2025 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBiochemistry

Jack W. SzostakORCID

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1 paper

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BiochemistryProceedings of the National Academy of SciencesPeer-reviewedMay 21, 2025

Nonenzymatic RNA copying with a potentially primordial genetic alphabet

Ziyuan Fang, Xiwen Jia, Yanfeng Xing, Jack W. Szostak

This paper investigates a primordial genetic alphabet using 2-thiouridine (s2U), 2-thiocytidine (s2C), inosine (I), and adenine (A), showing that their base pairs are isoenergetic and isomorphic, enabling balanced nucleotide incorporation in nonenzymatic RNA copying.

3 citations

DNA methylationproteomics

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