Nkrumah A. Grant

This study shows how a foreign aromatic catabolic pathway integrates with central metabolism in Methylobacterium extorquens, leading to substrate-specific metabolic trade-offs and cross-adaptation.

The paper generates a quorum-sensing competent transposon mutant library for Vibrio cholerae by transferring mutants into a wildtype background, revealing density-dependent epistasis and improving genetic context for studying pathogenesis.