MicrobiologybioRxivPreprint
Dual role of Toxoplasma gondii ROP5 and ROP18 for NLRP3 inhibition
Mateo Murillo-Léon, Aura M. Bastidas-Quintero, Shishir Singh…·Tobias Steinfeldt
This paper identifies vacuolar disruption as a trigger for NLRP3 inflammasome activation in Toxoplasma gondii infection and shows ROP5 and ROP18 inhibit IL-1β release by protecting the parasitophorous vacuole and interacting with GBP5.