Antagonists Perturb the MC2R MRAP Complex and Reshape Receptor Conformations
Ye Xin, Xingyu Qiu, Leonhard Hagen Urner…·Carol V. Robinson
This study uses mass spectrometry to show how MRAP and antagonists affect MC2R conformations and dynamics.
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University of OxfordORCID 0000-0002-4656-1706Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Ye Xin, Xingyu Qiu, Leonhard Hagen Urner…·Carol V. Robinson
This study uses mass spectrometry to show how MRAP and antagonists affect MC2R conformations and dynamics.
Nilanjana Banerjee, Manisankar Ganguly, Ashna Reyaz…·Arun K. Shukla
This study reveals an atypical activation mechanism of CXCR7, identifies its role as an opioid receptor, and highlights potential for novel pain therapeutics.
Zihao Wang, Guodong Cao, Miranda P. Collier…·Justin L. P. Benesch
The paper investigates how cardiac stress regulates Filamin C dimerisation through phosphorylation-modulated interactions with HSPB7, revealing evolutionary conservation of this mechanism.