Markus Gabriel Manz

This study shows that Tet2-mutant clonal hematopoiesis promotes while Dnmt3a-mutant clonal hematopoiesis inhibits breast cancer progression with age, identifying IL-1/CXCL2 inflammation as a therapeutic target.

The paper develops a mathematical model and Bayesian framework to evaluate CAR T-cell efficacy against AML, revealing antigen-specific resistance mechanisms.

This study shows that CAR-T therapy induces an immunosuppressive microenvironment, leading to T-cell dysfunction and resistance in B-ALL patients.

The paper identifies bacterial DNA remnants in blood immune cells of CRC and IBD patients, suggesting microbial translocation via intestinal barrier defects.

This study identifies circulating senescent myeloid cells as drivers of blood-brain barrier breakdown and neurodegeneration in LCH-ND.

The paper maps the dynamic interactions between hematopoietic stem cells and niche cells in the fetal liver using multi-omics approaches, revealing spatial and temporal changes in the microenvironment.

scROSHI identifies cell types without training data by using pre-existing gene sets and hierarchical relationships, outperforming methods in low-data and high-diversity scenarios.

SCIM matches single-cell measurements across technologies by learning a technology-invariant latent space and applying bipartite matching, achieving high accuracy in real-world datasets.

The paper describes an ultra-sensitive mass spectrometry method for proteomic analysis of FACS-isolated human hematopoietic stem and progenitor cells, revealing unique proteomic signatures and stemness-related biochemical processes.