Lumír Krejčí

The paper identifies replication environments associated with DNA breakage in cancer cell lines by integrating genomic and transcriptomic data.

This study identifies RIPR-1 as a novel BRC-2/BRCA2 interactor that regulates RAD-51 recruitment during meiotic homologous recombination, revealing BRCA2-independent pathways and stage-dependent constraints on DNA repair.

This paper identifies two distinct MUS81 inhibitors that enhance chemotherapy efficacy by impairing DNA repair in cancer cells.

The paper shows that Mus81 and Yen1 cleave D-loops to form half-crossover precursors in budding yeast.

The paper shows that Nup98 nucleoporins use phase separation to mobilize heterochromatic repair sites and exclude Rad51, promoting homologous recombination and genome integrity.