Sidney M. Becker

HM-DyadCap captures and maps hmC/mC CpG dyads in mammalian DNA, revealing their enrichment in gene bodies and depletion at transcription start sites.

The paper identifies tissue-specific readers and antireaders of symmetric and asymmetric hmC modifications in DNA using proteomics and promoter probe assays in human and mouse cells.

This study identifies natural nucleosides as activators of PKA in trypanosomatid pathogens, showing they replace cAMP in allosteric regulation through specific binding to CNB domains.