MicrobiologybioRxivPreprint
APP and APLP2 Kunitz Domains Are Potent Endogenous Inhibitors of TMPRSS2 and Respiratory Virus Infection
Jan Lawrenz, Shreyans Chatterjee, Armando Rodríguez Alfonso…·Jan Münch
DOI 10.64898/2026.08.13.744607
Author
Manfred Frick
Universität UlmORCID 0000-0002-4763-1104Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2025-2026 · peak 3/yrCo-Author Collaboration Network
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Curved chords = mutual co-authorship4 papers
Recent·Most cited
- MicrobiologybioRxivPreprint
Tonic interferons defend against respiratory viruses in primary human lung organoid-derived air-liquid interface cultures
Rinu Sivarajan, Paul C. Kirchgatterer, Jan Lawrenz…·Konstantin M. J. Sparrer
The paper demonstrates that tonic interferons are critical for early antiviral defense in human lung organoid-derived air-liquid interface cultures against HRV16.
DOI 10.64898/2025.12.10.693424 - Cell BiologybioRxivPreprint
Modeling Endothelial Dysfunction in Idiopathic Pulmonary Fibrosis: Bridging Mechanistic Insights and Translational Applications
Annalena Branz, Irina Shalashova, Anastasia M. Funk…·Muriel Lizé
This paper identifies PMVEC alterations in IPF using single-cell RNA sequencing and spatial transcriptomics, develops endothelial injury models, and validates functional assays for drug discovery.
- MicrobiologyAdvanced SciencePeer-reviewed
Trypstatin as a Novel TMPRSS2 Inhibitor with Broad-Spectrum 1 Efficacy Against Corona and Influenza Viruses
Jan Lawrenz, Lukas Wettstein, Armando Rodríguez…·Jan Münch
This paper identifies Trypstatin, a Kunitz-type protease inhibitor that inhibits TMPRSS2 and related proteases, showing broad-spectrum antiviral activity against SARS-CoV-2, influenza, and other respiratory viruses.