Konstantin M. J. Sparrer

This study identifies Regnases as antiviral restriction factors in humans, showing they inhibit RNA viruses but not DNA viruses, with varying substrate selectivity among the four Regnases.

This study identifies the IFN-STAT1/STAT5B-SOCS1 axis as a mechanism by which respiratory viruses activate autophagy, showing that targeting this pathway can inhibit virus replication without compromising innate immunity.

The paper identifies Laudanosine as an inhibitor of TPC2-dependent viral entry, effective against Ebola and related viruses without cytotoxicity.

CRISPR screens with replication-competent SIVcpz identify human antiviral factors limiting efficient viral replication after zoonotic transmission.

This study shows HSV infection increases ALS risk and promotes TDP-43 pathology through ICP0-mediated disruption of PML bodies.

The paper demonstrates that tonic interferons are critical for early antiviral defense in human lung organoid-derived air-liquid interface cultures against HRV16.

This study shows that ATM-deficient pancreatic cancers reprogram the tumor microenvironment via TGF-β-driven myCAF enrichment, and targeting this stromal axis with chemotherapy improves therapeutic efficacy.

The paper shows that the T9I mutation in the SARS-CoV-2 E protein confers autophagy resistance in Omicron variants, contributing to their spread.

This study reveals the structural basis of OAS2 regulation and its antiviral function, showing how it discriminates RNA length and restricts viruses like coronaviruses.

This study identifies Retinol Binding Protein 4 (RBP4) as a natural activator of latent HIV-1 through JAK/STAT5 and JNK pathways, offering a new strategy for reactivating viral reservoirs.

This study uses HIV-guided CRISPR to identify antiviral factors by analyzing sgRNA enrichment during viral replication.

The paper identifies key mutations in SARS-CoV-2 and bat coronaviruses that affect ACE2 receptor usage across different species and shows that vaccinated individuals' sera neutralize bat Sarbecovirus Spike proteins.

This study identifies ARF1 as a negative regulator of cGAS-STING signaling, showing it prevents type I IFN induction by regulating STING activation and recycling.

This study reveals how SARS-CoV-2 Nsp1 protein inhibits host translation and immune responses by binding ribosomes and blocking mRNA entry.