Peiyao A Zhao

The paper examines genome organization in human cells relative to nuclear locales, finding that gene expression and replication timing correlate with different nuclear structures and that LADs and iLADs compete for lamina attachment.

SPARROW integrates spatial transcriptomics and scRNA-seq to identify microenvironment zones and their influence on cell states and functions across tissues.

This study shows that cohesin-mediated loops in G1 phase determine the genomic location of replication origins in S phase by anchoring replication initiation zones.

This study shows that replication timing (RT) is essential for maintaining the global epigenetic state and genome compartmentalization in human cells, with RIF1 playing a central role in this process.

The paper defines the temporal choreography of DNA replication in mammalian cells using High Resolution Repli-Seq, revealing conserved replication timing patterns and cell-type-specific correlations with chromatin features.

The paper investigates how gene activation affects nuclear lamina interactions and shows that transcription can locally rewire these interactions without broadly altering chromosomal regions.

The paper identifies cis-regulatory elements (ERCEs) that control domain-wide replication timing, chromatin compartmentalization, and transcription in mouse embryonic stem cells.