Daniel Rosebrock

The paper integrates neuroimaging, omics, and single nucleus-RNA-Seq data to show glymphatic dysfunction in schizophrenia is linked to inflammation, aging, and cognitive decline.

The paper identifies a disease-associated microglial state in AD using transcriptomics and shows a compound can reverse it.

CAbiNet jointly visualizes cells and genes using a gene-cell graph and biMAP embedding for interactive exploration and biclustering.

The paper develops DNA- and RNA-based models combining immune and tumor features to predict outcomes of checkpoint inhibition in melanoma.

This study analyzes RNA-seq data from 6,700 normal tissues to identify somatic mutations and their association with age and tissue proliferation, finding tissue-specific cancer mutation hotspots.

PhylogicNDT statistically reconstructs cancer driver timing, subclonal phylogenies, and population dynamics from single- or multi-timepoint sequencing, revealing subtype-specific trajectories and therapy resistance evolution across 498 lung adenocarcinomas.

Four levers for cheaper cloud genomics on FireCloud: size virtual disks dynamically, tune VM provisioning from monitoring data, buy preemptible machines, and parallelise tasks at the right width.