Author

Christopher J. Troll

ORCID 0000-0002-4850-0288Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:variant calling· 1

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Andrew A. Mishin· 1 shared Ruby Tibet· 1 shared Tobin GrothiD· 1 shared Varsha RaoiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperGenomics

Andrew A. Mishin

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1 paper

Recent·Most cited

GenomicsThe Journal of Liquid BiopsyPeer-reviewedJan 3, 2026

End-repair causes methylation underestimation in cell-free DNA sequencing libraries

Tobin Groth, Andrew A. Mishin, Varsha Rao…·Christopher J. Troll

The paper shows that end-repair in double-stranded DNA libraries reduces CpG methylation estimates and tissue origin accuracy, while trimming read termini mitigates this bias but reduces coverage.

DOI 10.1016/j.jlb.2026.100455

DNA methylationexperimental assay

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