Yijun Chen

This paper develops a live bacterial system to reduce nicotine levels in blood and brain by enzymatic degradation in the gut, showing potential for non-systemic treatment of nicotine addiction.

This paper describes a gene conversion-driven strategy to reprogram a modular PKS in the cinnamomycin biosynthetic gene cluster to generate a novel macrolide.

This paper discovers a novel antibiotic, paenimycin, that targets multiple-drug-resistant bacteria through a dual-binding mechanism and shows no detectable resistance.

The paper identifies combinatorial CAR signaling domains that enhance macrophage function and tumor clearance through pooled screening and single-cell analysis.

This study compares KD values from SPR, ITC, and MST with Ki values from enzyme kinetics to assess their accuracy in determining binding affinity between small molecule inhibitors and protein targets.