Yujie Zhang

The paper shows codon optimality affects mRNA stability across human tissues, with energy metabolism and age modulating this effect.

The paper introduces HT-5Pseq, a method to study degradation-associated ribosome stalls, finding that Arginine before stop codons is enriched in these stalls, while TAA stop codons are more common in stable mRNAs.

The paper identifies chromatin-sensitive cryptic promoters in yeast that generate alternative protein isoforms through truncated mRNAs.