Roger Le Grand

This paper develops a third-generation IL-2 therapeutic that targets inflamed tissues via oxidation-specific epitopes, showing improved therapeutic benefit in multiple inflammation models.

The paper develops a PET-informed PBPK model using micro- and conventional dose data from non-human primates to predict human dolutegravir pharmacokinetics and inform first-in-human dose selection.

This paper models how memory CD8 T cells can drive post-treatment control of HIV by analyzing SIV-infected non-human primate data and developing a mathematical framework.

This study shows that blocking LILRB1 and LILRB2 with a dual-specific antibody enhances antiviral immune responses in SIV infection without adverse effects.

This study identifies transcriptomic and phenotypic changes in neutrophils associated with disease progression in Mtb-infected macaques.

This study develops a mechanistic model of viral and antibody dynamics in non-human primates to quantify correlates of protection against SARS-CoV-2 infection.

This study shows that Lactobacillus crispatus enrichment in the vaginal microbiota of non-human primates reduces systemic inflammation and increases anti-CT IgG production during Chlamydia trachomatis infection.

This study evaluates neuromuscular blockade in cynomolgus macaques using rocuronium and atracurium, finding equivalent blockade depth at human clinical doses and successful reversal with sugammadex.

This study uses mathematical modeling of SIV-infected macaques to show that early CD8 T-cell suppressive capacity predicts natural control of infection.

This study shows that seminal plasma inhibits Chlamydia trachomatis infection and modulates neutrophil function in an in vitro model of the female reproductive tract.

This paper shows that Sulfodyne(R), a stabilized Sulforaphane, reduces SARS-CoV-2-induced inflammation and disease severity in cell lines and animal models through mechanisms independent of NRF2 activation.

This study develops a non-human primate model of acute trachoma and characterizes the local immune response kinetics following Chlamydia trachomatis infection.

The paper evaluates and re-annotates DNA methylation probes from two microarrays for use in two nonhuman primate species, identifying reliable probes for high-throughput methylation analysis.

This paper shows that targeting MOG to skin macrophages via a fusion protein prevents EAE in macaques by inducing TGFβ-mediated peripheral tolerance.