Yiling Xu

FFPE-CUTAC is a new assay for analyzing FFPE tissues that provides regulatory and copy-number profiles, showing robustness over time and compatibility with RNA-seq.

The paper describes a summer research program where students learned chromatin profiling using FFPE-CUTAC, focusing on practical lab techniques and bioinformatics analysis.

The paper identifies RNA Polymerase II hypertranscription at histone genes in cancer FFPE samples, linking it to tumor progression and aneuploidy.

This study shows KMT2A oncoproteins drive lineage-switching and epigenetic resistance in leukemia by dynamically binding chromatin and persisting as ENL-marked lesions despite therapy.

The paper introduces WPS2, a high-throughput and high-sensitivity scRNA-seq method, which improves gene and transcript detection in low RNA-content cells and nuclei.

The paper shows centromeric arrays can expand and contract in somatic cell divisions, with expansion favored, and identifies RAD52 and PIF1 as required for array changes via break-induced replication.