Author

Javier Fernández-Mateos

Institute of Cancer ResearchORCID 0000-0002-4949-4131Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Assay:organoid / primary culture· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Ahmet AcariD· 2 shared Ahmet Bulent DogruliD· 1 shared Alex GraudenziiD· 1 shared Andrea BertottiiD· 1 shared Andrea SottorivaiD· 1 shared Bingjie CheniD· 1 shared Cenk SökmensüeriD· 1 shared Chela T. JamesiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Ahmet AcarORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJan 14, 2026

Molecular Profiling and High-Content Drug Screening of Metastatic Colorectal Cancer Organoids Reveal Evolutionary Mechanisms of Pan-KRAS Inhibitor Resistance

Gizem Damla Yalçın, Kubra Celikbas Yilmaz, Raffaella Klima…·Ahmet Acar

This study uses patient-derived organoids and single-cell RNA sequencing to investigate resistance mechanisms to pan-KRAS inhibitors in metastatic colorectal cancer.

1 citation

humanscRNA-seq

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Cancer BiologyCancer ResearchPeer-reviewedJun 11, 2025

Epigenetic heritability of cell plasticity drives cancer drug resistance through one-to-many genotype to phenotype mapping

Erica Aparecida de Oliveira, Salvatore Milite, Javier Fernández-Mateos…·Andrea Sottoriva

The paper shows how epigenetic heritability of cell plasticity contributes to cancer drug resistance through a one-to-many genotype-to-phenotype mapping.

51 citationstop 1%

humanorganoid / primary culture

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