Andrew J. Simpkin

The paper identifies age-dependent methylation quantitative trait loci (longitudinal mQTLs) across the lifespan using blood DNAm data from two cohorts, finding consistent genotype-by-age effects and associations with multiple phenotypes.

This study investigates how DNA methylation (DNAm) links racial discrimination, economic adversity, and air pollution to health inequities using epigenome-wide association analyses.

This study evaluates the reliability of DNA methylation measurements using the Illumina Infinium MethylationEPIC BeadChip at low DNA input levels, finding that 40ng DNA can be used with quality checks.

The paper investigates how childhood adversity during sensitive periods affects DNA methylation in genes regulating developmental plasticity using a gene set-based approach.

The paper assesses how changes in data versions and analytic methods affect the reproducibility of epigenome-wide association study results using the ALSPAC cohort.

This study examines how time-varying childhood adversity affects DNA methylation across development, finding persistent effects at age 15 and resolving differences by adolescence.

The paper analyzes DNA methylation changes across birth to late adolescence in two cohorts, finding widespread nonlinear changes and sex-specific patterns.

This study investigates the association between breastfeeding and DNA methylation changes in children and adolescents using data from the ALSPAC cohort, finding some consistent methylation sites linked to breastfeeding at ages 7 and 15-17.

This study examines how gestational age acceleration (GAA) relates to weight and height trajectories from birth to 10 years, finding initial increases in birth weight and height that reverse later in childhood.

The paper identifies impaired slow-wave and spindle coordination during NREM sleep in schizophrenia patients as predictors of memory consolidation deficits.

This study identifies 40 CpG sites with differential methylation at age 7 linked to adversity exposure timing, showing infancy as a sensitive period for DNAm changes.

Combining nearby CpG summary statistics by inverse-variance weighted meta-analysis holds false positives at the nominal level where comb-p and DMRcate inflate, and supports multi-cohort meta-analysis.

The paper examines how childhood adversity exposure affects epigenetic aging using DNA methylation clocks in children, finding that timing and type of adversity exposure significantly influence biological age.

This study investigates the association between CpG methylation and educational attainment, finding limited significant associations that may be influenced by confounding factors.