Author

Martin J.S. Dyer

University of LeicesterORCID 0000-0002-5033-2236Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Amy Hamilton AndreottiiD· 2 shared D. Bruce Fulton· 2 shared Raji E. JosephiD· 2 shared Robert G. BrittoniD· 2 shared Thomas E. WalesiD· 2 shared Andrea G. S. PepperiD· 1 shared Chris J. PepperiD· 1 shared David Yin-wei LiniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

Amy Hamilton AndreottiORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 17, 2026

BTK dynamics and function are differentially influenced by distinct covalent inhibitor warhead chemistries.

Raji E. Joseph, Robert G. Britton, David Yin-wei Lin…·Amy Hamilton Andreotti

This study compares the effects of different warhead chemistries in covalent inhibitors on BTK dynamics and function, showing that 2-butynamide induces conformational heterogeneity and reduced efficacy compared to acrylamide.

DOI 10.64898/2026.05.07.723540

humanexperimental assay

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BiochemistryeLifePeer-reviewedNov 19, 2024

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.

Raji E. Joseph, Thomas E. Wales, Sandrine Jayne…·Amy Hamilton Andreotti

This study examines how different BTK inhibitors affect BTK conformation and explains resistance mutation patterns in CLL patients.

3 citations

humanprotein structure

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Systems Biologynpj Systems Biology and ApplicationsPeer-reviewedJun 6, 2023

Computational modeling of DLBCL predicts response to BH3-mimetics.

Ielyaas Cloete, Victoria M. Smith, Ross A. Jackson…·Simon A. Mitchell

This study uses computational systems biology to predict DLBCL cell response to BH3-mimetics by modeling molecular variability and genetic lesions.

7 citations

humanstatistical model

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