Amy Hamilton Andreotti

This study compares the effects of different warhead chemistries in covalent inhibitors on BTK dynamics and function, showing that 2-butynamide induces conformational heterogeneity and reduced efficacy compared to acrylamide.

This study shows that small-molecule inhibitors of Btk can control its membrane assembly through allosteric effects, independent of catalytic activity.

This study demonstrates that AlphaFold3 can effectively discover novel covalent inhibitors for kinases through virtual screening, outperforming existing methods and validating predictions with co-crystallography.

This study examines how different BTK inhibitors affect BTK conformation and explains resistance mutation patterns in CLL patients.