Luke A. Sarre

This paper uses 6-base sequencing to analyze DNA modifications in cerebrospinal fluid cell-free DNA, providing insights into neurodegenerative biology for liquid biopsy applications.

The paper profiles 6mA methylation in 18 eukaryotes and finds it is linked to transcription and associated with H3K4me3-enriched nucleosomes, but is lost in major multicellular lineages.

The paper investigates the evolutionary origins of DNA methylation, finding it was likely acquired from bacterial donors to silence transposable and viral elements across eukaryotes.

The paper investigates viral lateral gene transfer in Acanthamoeba, showing viral insertions are epigenetically silenced and subject to deterioration over time.

The paper analyzes methylomes in annelids to show ancestral epigenetic erosion during development and aging, with gene body methylation linked to transcription and TE silencing.

The paper shows that DNA methylation in Amoebidium appalachense silences endogenized giant viruses, contributing 14% of its genes and revealing a dynamic process of viral integration and purging.