Upamanyu Ghose

This study uses brain-genotype scores to identify genetic associations with plasma proteins, finding 116 significant associations after FDR correction that conventional SNP models miss.

This study shows that mechanical confinement causes mitochondria to relocate to the nucleus, leading to a nuclear ATP surge that supports DNA repair and cell cycle progression.

This study identifies TLR2 as a target to counteract adaptation to ARF6 depletion in KRAS-driven PDAC, reducing proliferation, migration, and invasion.

This study identifies 262 STRs significantly associated with MRI-derived grey matter volumes in UK Biobank participants, with 12 associations replicated and no nearby SNPs in linkage disequilibrium.