Barbara Xiong

The paper introduces N-Orbit, a mathematical model for comparing tissue microenvironments by encoding cell type composition and spatial relationships, showing improved performance over existing metrics in neighborhood discrimination and clinical prediction.

This study creates a longitudinal multiomic atlas of pediatric high-grade glioma, revealing distinct tumor cell states and therapeutic targets not seen in adult glioblastoma.

This study maps human bone marrow niches using single-cell transcriptomics and proteomic imaging, identifying distinct cellular environments and their roles in hematopoiesis and AML.