BiochemistrybioRxivPreprint
Reconstitution of +1 nucleosome transcription reveals coordinated functions of SAGA, Mediator, and TFIIH
Shigeki Nagai, Dong-Hua Chen, Rayees U.H. Mattoo…·Roger D. Kornberg
This study reconstitutes transcription through the +1 nucleosome using purified yeast factors and finds that SAGA, Mediator, and TFIIH coordinate to overcome nucleosome barriers and regulate transcription initiation.
DOI 10.64898/2026.09.24.754195