Olivier Boucherat

This study identifies hypusine signaling as a driver of vascular smooth muscle cell proliferation in restenosis and shows that inhibiting DHPS reduces neointimal hyperplasia in preclinical models and human tissue.

This study identifies a sexually dimorphic NLRP3 signaling pathway in right ventricular failure, showing estrogen receptor α mediates protection against NLRP3-induced contractile dysfunction in cardiomyocytes.

This study develops preclinical models of Group-2 pulmonary hypertension and shows that levosimendan improves cardiac function and reduces pulmonary vascular inflammation and remodeling.

The paper identifies FABP4/5 as key regulators of endothelial glycolysis and arterial programming in pulmonary hypertension using single-cell and spatial transcriptomics.

The study identifies integrin α5β1 as a key driver of pulmonary vascular remodeling in PAH and shows its inhibition improves hemodynamics and RV function in preclinical models.

This study identifies ATP-citrate lyase as a driver of vascular remodeling in pulmonary hypertension and coronary artery disease, showing its inhibition can reverse pathological changes.

This paper classifies PAH-related genes based on evidence strength using a semi-quantitative scoring system, identifying twelve genes with definitive evidence and recommending their inclusion in genetic testing panels.