Author
Thomas O. McDonald
Harvard UniversityORCID 0000-0002-5272-0187Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2023-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 26 mutual co-author links4 papers
Recent·Most cited
- Cancer BiologybioRxivPreprint
Multi-region biopsies and patient-derived neurosphere cultures reveal spatial divergence in glioblastoma.
Roberto Salatino, Jacob Geisberg, Arantxa Romero-Toledo…·Michalina Janiszewska
This study shows that multi-region neurospheres from glioblastoma tumors retain spatial diversity and drug response patterns linked to their original biopsies, highlighting their importance for modeling intratumor heterogeneity.
DOI 10.64898/2026.04.07.717044 - Systems BiologybioRxivPreprint
BESTDR: Bayesian quantification of mechanism-specific drug response in cell culture
Thomas O. McDonald, Simone Bruno, James P. Roney…·Franziska Michor A
BESTDR quantifies drug response mechanisms using Bayesian modeling of cell state transitions, improving accuracy in dose-response analysis across cell lines.
DOI 10.1101/2025.02.05.636681 - Systems BiologybioRxivPreprint
Reconstruction of single cell lineage trajectories and identification of diversity in fates during the epithelial-to-mesenchymal transition
Yu-Chen Cheng, Yun Zhang, Shubham Tripathi…·Franziska Michor A
This study uses optimal transport analysis on scRNA-seq data to reconstruct EMT trajectories in MCF10A cells, identifying three distinct fates and novel genes associated with different EMT states.