Briana C. Rodriguez

This paper identifies a cytochrome P450 gene variant that contributes to benzimidazole resistance in nematodes, independent of beta-tubulin mutations.

The paper identifies three genomic regions in C. elegans associated with natural variation in macrocyclic lactone response, including two novel loci and one previously known locus.

This study identifies extreme allelic heterogeneity in the ben-1 gene of C. elegans as a major determinant of natural resistance to albendazole, revealing multiple mechanisms of benzimidazole resistance.