Thomas Holst‐Hansen

This paper uses a computational model to show that pancreatic islets can switch between transient and persistent inflammation modes based on feedback loops and islet size.

The paper shows that NF-κB dynamics in fibroblasts encode cytokine dose, duration, and distance through wave-like propagation, creating spatially defined gene expression zones.

The paper investigates how zygosity affects gene expression in a bimodal distribution by analyzing HCMV-infected donors and using mathematical models to identify feedback mechanisms in gene regulatory circuits.