Author

Tristan Félix

InsermORCID 0000-0002-5331-3153Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Annarita MiccioiD· 2 shared Anne ChalumeauiD· 2 shared Giulia HardouiniD· 2 shared Oriana RomanoiD· 2 shared Panagiotis AntoniouiD· 2 shared Alexandra TachtsidiiD· 1 shared Bochra Mlayah· 1 shared Giacomo FratiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersMolecular Biology

Annarita MiccioORCID

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2 papers

Recent·Most cited

Molecular BiologyCell Reports MedicinePeer-reviewedSep 27, 2025

Multiplex base editing of BCL11A regulatory elements to treat sickle cell disease

Letizia Fontana, Pierre Martinucci, Simone Amistadi…·Annarita Miccio

This study uses multiplex base editing to target BCL11A enhancers, increasing fetal hemoglobin production and reducing sickle cell disease symptoms without causing significant genomic damage.

8 citationstop 4%

humanCRISPR screen

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BioengineeringMolecular TherapyPeer-reviewedJul 22, 2024

Safety and efficacy study of CRISPR/Cas9 treatment of sickle cell disease in clinically relevant conditions highlights disease-specific response

Giacomo Frati, Mégane Brusson, Gilles Sartre…·Annarita Miccio

This study evaluates the safety and efficacy of CRISPR/Cas9-mediated HbF reactivation in sickle cell disease by testing it in patient-derived HSPCs and shows it is effective but has off-target effects.

32 citationstop 1%

humangenetic perturbation / CRISPR

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