Alessandro Aiuti

The paper analyzes HSPC aging across the lifespan, finding age-related epigenetic dysregulation and impaired response to proliferative stress, using xenotransplantation models.

This study shows that WASp in macrophages prevents inflammation by maintaining nuclear integrity under mechanical stress, linking mechano-sensing to inflammatory responses.

The paper identifies rare loss-of-function variants in type I IFN immunity genes associated with severe COVID-19, particularly in younger patients with recessive inheritance.